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The secretion of VEGF‘s, chemokines CXCL1 and CXCL8, as well ashypoxia inducible factor 1 alpha (HIF1a) by TAMs is regulated by transcription factors NF-kB, STAT3, and AP-1 (Grivennikov 2010).
A recent meta-analysis of approximately50 different studies suggested that depression is a riskfactor for AD.
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